Catecholamine use is associated with enterocyte damage in critically ill patients.
Identifieur interne : 003077 ( Main/Exploration ); précédent : 003076; suivant : 003078Catecholamine use is associated with enterocyte damage in critically ill patients.
Auteurs : Gaël Piton [Australie] ; Benoit Cypriani ; Jacques Regnard ; Cyrille Patry ; Marc Puyraveau ; Gilles CapellierSource :
- Shock (Augusta, Ga.) [ 1540-0514 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Catécholamines (effets indésirables), Catécholamines (sang), Catécholamines (usage thérapeutique), Choc septique (physiopathologie), Choc septique (sang), Entérocytes (), Entérocytes (anatomopathologie), Femelle, Humains, Hémodynamique, Intestin grêle (), Intestin grêle (anatomopathologie), Maladie grave, Mâle, Norépinéphrine (administration et posologie), Odds ratio, Pronostic, Protéines de liaison aux acides gras (sang), Soins de réanimation, Sujet âgé, Unités de soins intensifs, Vitesse du flux sanguin, Épinéphrine (administration et posologie), Études prospectives.
- MESH :
- administration et posologie : Norépinéphrine, Épinéphrine.
- anatomopathologie : Entérocytes, Intestin grêle.
- effets indésirables : Catécholamines.
- physiopathologie : Choc septique.
- sang : Catécholamines, Choc septique, Protéines de liaison aux acides gras.
- usage thérapeutique : Catécholamines.
- Adulte d'âge moyen, Entérocytes, Femelle, Humains, Hémodynamique, Intestin grêle, Maladie grave, Mâle, Odds ratio, Pronostic, Soins de réanimation, Sujet âgé, Unités de soins intensifs, Vitesse du flux sanguin, Études prospectives.
English descriptors
- KwdEn :
- Aged, Blood Flow Velocity, Catecholamines (adverse effects), Catecholamines (blood), Catecholamines (therapeutic use), Critical Care, Critical Illness, Enterocytes (drug effects), Enterocytes (pathology), Epinephrine (administration & dosage), Fatty Acid-Binding Proteins (blood), Female, Hemodynamics, Humans, Intensive Care Units, Intestine, Small (drug effects), Intestine, Small (pathology), Male, Middle Aged, Norepinephrine (administration & dosage), Odds Ratio, Prognosis, Prospective Studies, Shock, Septic (blood), Shock, Septic (physiopathology).
- MESH :
- chemical , administration & dosage : Epinephrine, Norepinephrine.
- chemical , adverse effects : Catecholamines.
- chemical , blood : Catecholamines, Fatty Acid-Binding Proteins.
- chemical , therapeutic use : Catecholamines.
- blood : Shock, Septic.
- drug effects : Enterocytes, Intestine, Small.
- pathology : Enterocytes, Intestine, Small.
- physiopathology : Shock, Septic.
- Aged, Blood Flow Velocity, Critical Care, Critical Illness, Female, Hemodynamics, Humans, Intensive Care Units, Male, Middle Aged, Odds Ratio, Prognosis, Prospective Studies.
Abstract
Small bowel damage is frequent but underdiagnosed among critically ill patients with shock. High catecholamine doses may have a deleterious effect on mesenteric blood flow. Plasma intestinal fatty acid-binding protein (I-FABP) concentration is a marker of enterocyte damage, whereas plasma citrulline concentration is a marker of functional enterocyte mass. We hypothesized that high doses of catecholamines in critically ill patients may be associated with enterocyte damage. This study aimed to determine the link between catecholamine use and dose with enterocyte damage. This is a prospective observational study performed in a large regional university teaching hospital. Critically ill patients requiring epinephrine and/or norepinephrine at admission to a medical intensive care unit (ICU) were included, as well as controls not receiving catecholamines. We evaluated at admission plasma I-FABP and citrulline concentrations, abdominal perfusion pressure (APP), and variables relating to prognosis and treatment. Patients were categorized according to the quartiles of catecholamine dose at ICU admission. Sixty critically ill patients receiving catecholamines and 27 not receiving catecholamines were included. Plasma I-FABP was higher among patients receiving catecholamine than in controls. Among patients receiving catecholamines, a dose of 0.48 γ kg min or more at ICU admission was associated with a higher I-FABP concentration. A Sepsis-related Organ Failure Assessment score higher than 11 and plasma I-FABP more than 524 pg mL at ICU admission were independently associated with 28-day mortality (odds ratio, 4.0 [1.24-12.95] and odds ratio, 4.90 [1.44-16.6], respectively). Catecholamine use is associated with I-FABP elevation in critically ill patients. Critically ill patients receiving more than 0.48 γ kg min of epinephrine and/or norepinephrine at ICU admission have high I-FABP concentrations. This suggests that enterocyte damage reflects the severity of shock, and an adverse effect of catecholamines per se is possible.
DOI: 10.1097/SHK.0000000000000327
PubMed: 25565647
Affiliations:
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Le document en format XML
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<term>Catecholamines (blood)</term>
<term>Catecholamines (therapeutic use)</term>
<term>Critical Care</term>
<term>Critical Illness</term>
<term>Enterocytes (drug effects)</term>
<term>Enterocytes (pathology)</term>
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<term>Catécholamines (usage thérapeutique)</term>
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<term>Entérocytes ()</term>
<term>Entérocytes (anatomopathologie)</term>
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<term>Humains</term>
<term>Hémodynamique</term>
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<term>Intestin grêle (anatomopathologie)</term>
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<term>Mâle</term>
<term>Norépinéphrine (administration et posologie)</term>
<term>Odds ratio</term>
<term>Pronostic</term>
<term>Protéines de liaison aux acides gras (sang)</term>
<term>Soins de réanimation</term>
<term>Sujet âgé</term>
<term>Unités de soins intensifs</term>
<term>Vitesse du flux sanguin</term>
<term>Épinéphrine (administration et posologie)</term>
<term>Études prospectives</term>
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<front><div type="abstract" xml:lang="en">Small bowel damage is frequent but underdiagnosed among critically ill patients with shock. High catecholamine doses may have a deleterious effect on mesenteric blood flow. Plasma intestinal fatty acid-binding protein (I-FABP) concentration is a marker of enterocyte damage, whereas plasma citrulline concentration is a marker of functional enterocyte mass. We hypothesized that high doses of catecholamines in critically ill patients may be associated with enterocyte damage. This study aimed to determine the link between catecholamine use and dose with enterocyte damage. This is a prospective observational study performed in a large regional university teaching hospital. Critically ill patients requiring epinephrine and/or norepinephrine at admission to a medical intensive care unit (ICU) were included, as well as controls not receiving catecholamines. We evaluated at admission plasma I-FABP and citrulline concentrations, abdominal perfusion pressure (APP), and variables relating to prognosis and treatment. Patients were categorized according to the quartiles of catecholamine dose at ICU admission. Sixty critically ill patients receiving catecholamines and 27 not receiving catecholamines were included. Plasma I-FABP was higher among patients receiving catecholamine than in controls. Among patients receiving catecholamines, a dose of 0.48 γ kg min or more at ICU admission was associated with a higher I-FABP concentration. A Sepsis-related Organ Failure Assessment score higher than 11 and plasma I-FABP more than 524 pg mL at ICU admission were independently associated with 28-day mortality (odds ratio, 4.0 [1.24-12.95] and odds ratio, 4.90 [1.44-16.6], respectively). Catecholamine use is associated with I-FABP elevation in critically ill patients. Critically ill patients receiving more than 0.48 γ kg min of epinephrine and/or norepinephrine at ICU admission have high I-FABP concentrations. This suggests that enterocyte damage reflects the severity of shock, and an adverse effect of catecholamines per se is possible.</div>
</front>
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<tree><noCountry><name sortKey="Capellier, Gilles" sort="Capellier, Gilles" uniqKey="Capellier G" first="Gilles" last="Capellier">Gilles Capellier</name>
<name sortKey="Cypriani, Benoit" sort="Cypriani, Benoit" uniqKey="Cypriani B" first="Benoit" last="Cypriani">Benoit Cypriani</name>
<name sortKey="Patry, Cyrille" sort="Patry, Cyrille" uniqKey="Patry C" first="Cyrille" last="Patry">Cyrille Patry</name>
<name sortKey="Puyraveau, Marc" sort="Puyraveau, Marc" uniqKey="Puyraveau M" first="Marc" last="Puyraveau">Marc Puyraveau</name>
<name sortKey="Regnard, Jacques" sort="Regnard, Jacques" uniqKey="Regnard J" first="Jacques" last="Regnard">Jacques Regnard</name>
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<country name="Australie"><noRegion><name sortKey="Piton, Gael" sort="Piton, Gael" uniqKey="Piton G" first="Gaël" last="Piton">Gaël Piton</name>
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